sEH/FLAP-IN-1

• UNSPSC Description:

  sEH/FLAP-IN-1 (Compound 46A) is a sEH/FLAP inhibitor. sEH/FLAP-IN-1 inhibits 5-LOX product formation in SACM-stimulated PBMCs (EC50: 11 nM). sEH/FLAP-IN-1 inhibit sEH (EC50: 18 nM) and thromboxane production. sEH/FLAP-IN-1 can be used for research of inflammatory diseases[1].

• Target Antigen:

  Epoxide Hydrolase; FLAP

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/seh-flap-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=CC(NC(NC2=CC=C(N=C2)OCC3=NC4=CC=CN=C4S3)=O)=CC=C1Cl

• Molecular Weight:

  446.31

• References & Citations:

  [1]Schoenthaler M, et al. Novel thiazolopyridine derivatives of diflapolin as dual sEH/FLAP inhibitors with improved solubility. Bioorg Chem. 2023 Oct;139:106685.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported