sEH/FLAP-IN-1

sEH/FLAP-IN-1

• UNSPSC Description: sEH/FLAP-IN-1 (Compound 46A) is a sEH/FLAP inhibitor. sEH/FLAP-IN-1 inhibits 5-LOX product formation in SACM-stimulated PBMCs (EC50: 11 nM). sEH/FLAP-IN-1 inhibit sEH (EC50: 18 nM) and thromboxane production. sEH/FLAP-IN-1 can be used for research of inflammatory diseases[1].
• Target Antigen: Epoxide Hydrolase; FLAP
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/seh-flap-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: ClC1=CC(NC(NC2=CC=C(N=C2)OCC3=NC4=CC=CN=C4S3)=O)=CC=C1Cl
• Molecular Weight: 446.31
• References & Citations: [1]Schoenthaler M, et al. Novel thiazolopyridine derivatives of diflapolin as dual sEH/FLAP inhibitors with improved solubility. Bioorg Chem. 2023 Oct;139:106685.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported