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SEH/FLAP-IN-1

CAT: 0804-HY-156329Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-156329Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SEH/FLAP-IN-1 (Compound 46A) is a sEH/FLAP inhibitor. sEH/FLAP-IN-1 inhibits 5-LOX product formation in SACM-stimulated PBMCs (EC50: 11 nM) . sEH/FLAP-IN-1 inhibit sEH (EC50: 18 nM) and thromboxane production. sEH/FLAP-IN-1 can be used for research of inflammatory diseases[1].
UNSPSC
12352005
Target
Epoxide Hydrolase; FLAP
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/seh-flap-in-1.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC(NC(NC2=CC=C(N=C2)OCC3=NC4=CC=CN=C4S3)=O)=CC=C1Cl
Molecular Formula
C19H13Cl2N5O2S
Molecular Weight
446.31
References & Citations
[1]Schoenthaler M, et al. Novel thiazolopyridine derivatives of diflapolin as dual sEH/FLAP inhibitors with improved solubility. Bioorg Chem. 2023 Oct;139:106685.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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