Axl-IN-6

• Description :

  Axl-IN-6 (compound 14) is an orally active and potent AXL inhibitor. Axl-IN-6 is well tolerated and significantly inhibits the tumor growth in MV-4-11 subcutaneous xenograft model[1].

• UNSPSC :

  12352005

• Target :

  TAM Receptor

• Type :

  Reference compound

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/axl-in-6.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(OC1=CC=C(C=C1)C2=CC=CC3=CN=C(N=C32)NC4=CC5=C(CC[C@@H](CC5)N6CCCC6)C=C4)C

• Molecular Formula :

  C32H36N4O

• Molecular Weight :

  492.65

• References & Citations :

  [1]Zhang LL, et al. Discovery a series of quinazolin derivatives as potent AXL inhibitors. Eur J Med Chem. 2022 Apr 6;237:114316.[published online ahead of print, 2022 Apr 6]. Eur J Med Chem. 2022;237:114316.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Axl

• CAS Number :

  [2642224-22-2]