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Axl-IN-6

CAT: 0804-HY-146615Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146615Size:1 Each
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Description
Axl-IN-6 (compound 14) is an orally active and potent AXL inhibitor. Axl-IN-6 is well tolerated and significantly inhibits the tumor growth in MV-4-11 subcutaneous xenograft model[1].
CAS Number
2642224-22-2
UNSPSC
12352005
Target
TAM Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/axl-in-6.html
Solubility
10 mM in DMSO
Smiles
CC(OC1=CC=C(C=C1)C2=CC=CC3=CN=C(N=C32)NC4=CC5=C(CC[C@@H](CC5)N6CCCC6)C=C4)C
Molecular Formula
C32H36N4O
Molecular Weight
492.65
References & Citations
[1]Zhang LL, et al. Discovery a series of quinazolin derivatives as potent AXL inhibitors. Eur J Med Chem. 2022 Apr 6;237:114316.[published online ahead of print, 2022 Apr 6]. Eur J Med Chem. 2022;237:114316.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Axl

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