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EGFR-IN-51

CAT: 0804-HY-146471Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146471Size:1 Each
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Description
EGFR-IN-51 (Compound 6) is a potent EGFR inhibitor with IC50 values of 0.493, 102.60 and 461.63 µM against EGFR, EGFR L858R-TK and EGFR T790M-TK, respectively. EGFR-IN-51 shows cytotoxic activity against cancer cell lines and induces apoptosis[1].
CAS Number
2418549-32-1
UNSPSC
12352005
Target
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-51.html
Solubility
10 mM in DMSO
Smiles
S=C(NC1=C2C=CC=CC2=NC3=C1C=CC=C3)NC4=CC=C5OCOC5=C4
Molecular Formula
C21H15N3O2S
Molecular Weight
373.43
References & Citations
[1]Abbas SY, et al. Synthesis and anticancer activity of thiourea derivatives bearing a benzodioxole moiety with EGFR inhibitory activity, apoptosis assay and molecular docking study. Eur J Med Chem. 2020 Jul 15;198:112363.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1

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