Ro-51

• Description :

  Ro-51 is a potent and selective dual P2X3/P2X2/3 antagonist, with IC50 of 2 nM and 5 nM for P2X3 and P2X2/3, respectively. Ro-51 can be used for the research for pain[1][2].

• UNSPSC :

  12352005

• Target :

  P2X Receptor

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ro-51.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OCC(NC1=NC=C(OC2=CC(I)=C(OC)C=C2C(C)C)C(N)=N1)CO

• Molecular Formula :

  C17H23IN4O4

• Molecular Weight :

  474.29

• References & Citations :

  [1]Alam Jahangir, et al. Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X (3) /P2X (2/3) antagonist for the treatment of pain. Bioorg Med Chem Lett. 2009 Mar 15;19 (6) :1632-5.|[2]Alexandre Serrano, et al. Differential Expression and Pharmacology of Native P2X Receptors in Rat and Primate Sensory Neurons. J Neurosci. 2012 Aug 22; 32 (34) : 11890–11896.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  P2X3 Receptor

• CAS Number :

  [1050670-85-3]