Ro-51

• Description:

  Ro-51 is a potent and selective dual P2X3/P2X2/3 antagonist, with IC50 of 2 nM and 5 nM for P2X3 and P2X2/3, respectively. Ro-51 can be used for the research for pain[1][2].

• UNSPSC:

  12352005

• Target:

  P2X Receptor

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ro-51.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OCC(NC1=NC=C(OC2=CC(I)=C(OC)C=C2C(C)C)C(N)=N1)CO

• Molecular Formula:

  C17H23IN4O4

• Molecular Weight:

  474.29

• References & Citations:

  [1]Alam Jahangir, et al. Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X (3) /P2X (2/3) antagonist for the treatment of pain. Bioorg Med Chem Lett. 2009 Mar 15;19 (6) :1632-5.|[2]Alexandre Serrano, et al. Differential Expression and Pharmacology of Native P2X Receptors in Rat and Primate Sensory Neurons. J Neurosci. 2012 Aug 22; 32 (34) : 11890–11896.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  P2X3 Receptor

• CAS Number:

  1050670-85-3