Ro-51

CAT: 0804-HY-14485-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-14485-01Size:5 mg
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Description
Ro-51 is a potent and selective dual P2X3/P2X2/3 antagonist, with IC50 of 2 nM and 5 nM for P2X3 and P2X2/3, respectively. Ro-51 can be used for the research for pain[1][2].
CAS Number
[1050670-85-3]
UNSPSC
12352005
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ro-51.html
Solubility
10 mM in DMSO
Smiles
OCC(NC1=NC=C(OC2=CC(I)=C(OC)C=C2C(C)C)C(N)=N1)CO
Molecular Formula
C17H23IN4O4
Molecular Weight
474.29
References & Citations
[1]Alam Jahangir, et al. Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X (3) /P2X (2/3) antagonist for the treatment of pain. Bioorg Med Chem Lett. 2009 Mar 15;19 (6) :1632-5.|[2]Alexandre Serrano, et al. Differential Expression and Pharmacology of Native P2X Receptors in Rat and Primate Sensory Neurons. J Neurosci. 2012 Aug 22; 32 (34) : 11890–11896.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2X3 Receptor

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