Products for Research Use Only
RegisterLogin

EGFR/BRAF-IN-1

CAT: 0804-HY-115933Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-115933Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
EGFR/BRAF-IN-1 (compound 21), a 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivative, is a potent EGFR/BRAF inhibitor with an IC50 of 45 nM for BRAFV600E. EGFR/BRAF-IN-1 inhibits cancer cell proliferation (GI50=35 nM) . EGFR/BRAF-IN-1 shows good antioxidant activity[1].
CAS Number
2906174-89-6
UNSPSC
12352005
Target
EGFR; Raf
Type
Reference compound
Related Pathways
JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-braf-in-1.html
Solubility
10 mM in DMSO
Smiles
CCOCC1=C2C(N(CC(N2C3=CC=C(C=C31)Cl)=O)CCC4=CC=C(C=C4)N5CCOCC5)=O
Molecular Formula
C26H28ClN3O4
Molecular Weight
481.97
References & Citations
[1]Hesham A M Gomaa, et al.Optimization and SAR investigation of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as EGFR and BRAF V600E dual inhibitors with potent antiproliferative and antioxidant activities. Bioorg Chem. 2022 Jan 19;120:105616.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf; EGFR/ErbB1/HER1

Related Products

CatalogName
HY-41747BRAF ligand-1
HY-146442BRAF V600E/CRAF-IN-1
HY-146491VEGFR-2/BRAF-IN-1
HY-19617EGFR-IN-1
HY-175726BRAF ligand-Linker Conjugate 1
HY-137487-01PROTAC BRAF-V600E degrader-1
HY-10247-01BRAF inhibitor
HY-168492-01TrxR/EGFR-IN-1
HY-168073EGFR/VEGFR2-IN-1
HY-161136EGFR/STAT3-IN-1

Alternative Products

CatalogName
MBS5805864EGFR/BRAF-IN-1
sc-80543EGFR (EGFR.1)
PPL01135-4aPCD513B-1-BRAF
BZ0249-2PcDNA3.1-BRAF
GTR19265201-01BRAF ligand-1
308162-01BRAF
MBS5814939VEGFR-2/BRAF-IN-1
PPL01135-4bPCD513B-1-BRAF (V600E)
PVTB01135-4apCD513B-1-BRAF Plasmid
GTR19185204-01BRAF V600E/CRAF-IN-1

Popular Products