PROTAC EGFR degrader 10

PROTAC EGFR degrader 10

• CAS Number: 3034244-56-6
• UNSPSC Description: PROTAC EGFR degrader 10 (Compound B56) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC50 Ki of 37 nM. PROTAC EGFR degrader 10 degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC50 [1].
• Target Antigen: EGFR; FAK; PROTACs
• Type: Reference compound
• Related Pathways: JAK/STAT Signaling;PROTAC;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-egfr-degrader-10.html
• Smiles: O=C1C(C2=CC=C(N3CCC(OCCN(CC4)CCN4C(CC5)CCN5C(C(CC)=C6)=CC(OC)=C6NC7=NC=C(Cl)C(NC8=CC=C(OC)C=C8N(S(=O)(C)=O)C)=N7)CC3)C=C2)CCC(N1)=O
• Molecular Weight: 973.62
• References & Citations: [1]Han W, et al., Compound for targeted protein degradation, and use thereof. WO2024072178A1
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported