PROTAC EGFR degrader 4
CAT:
804-HY-146349-03
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PROTAC EGFR degrader 4
- CAS Number: 2882845-50-1
- UNSPSC Description: PROTAC EGFR degrader 4 is a potent PROTAC targeting mutant EGFR.PROTAC EGFR degrader 4 induces EGFRdel19 and EGFRL858R/T790M degradation with DC50s of 0.51 and 126 nM, respectively. PROTAC EGFR degrader 4 significantly inhibits growth of HCC827 and H1975 cell lines with IC50s of 0.83 and 203.1 nM, respectively. Induced EGFR degradation is related to autophagy[1].
- Target Antigen: Autophagy; EGFR; PROTACs
- Type: Reference compound
- Related Pathways: Autophagy;JAK/STAT Signaling;PROTAC;Protein Tyrosine Kinase/RTK
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/protac-egfr-degrader-4.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCCCN4CCN(CC4)C5=CC=C(C=C5)NC6=NC=C7N=C(N(C7=N6)C8CCCC8)NC9=CC=CC=C9)=O)=O)O)=O
- Molecular Weight: 995.29
- References & Citations: [1]Hong-Yi Zhao, Discovery of potent small molecule PROTACs targeting mutant EGFR. Eur J Med Chem. 2020 Dec 15;208:112781.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported