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AChE/BChE-IN-9

CAT: 0804-HY-146399Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146399Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AChE/BChE-IN-9 (Compound 7a) is a potent, orally active AChE and BChE inhibitor with IC50 values of 5.74 μM and 14.05 μM against hAChE and eqBChE, respectively. AChE/BChE-IN-9 is also an efficacious antioxidant with an IC50 of 57.35 μM. AChE/BChE-IN-9 is able to chelate iron and modulates aggregation of amyloid β1-42. AChE-IN-16 can cross the BBB[1].
CAS Number
2761542-55-4
UNSPSC
12352005
Target
Cholinesterase (ChE) ; ROS Kinase
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-bche-in-9.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C=CC(/C=C/C(NCC(NC2=CC=C3NC=CC3=C2)=O)=O)=C1)O
Molecular Formula
C20H19N3O4
Molecular Weight
365.38
References & Citations
[1]Singh YP, et al. Design, synthesis and biological evaluation of novel naturally-inspired multifunctional molecules for the management of Alzheimer's disease. Eur J Med Chem. 2020 Jul 15;198:112257.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE

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