AChE/BChE-IN-9

• UNSPSC Description:

  AChE/BChE-IN-9 (Compound 7a) is a potent, orally active AChE and BChE inhibitor with IC50 values of 5.74 μM and 14.05 μM against hAChE and eqBChE, respectively. AChE/BChE-IN-9 is also an efficacious antioxidant with an IC50 of 57.35 μM. AChE/BChE-IN-9 is able to chelate iron and modulates aggregation of amyloid β1-42. AChE-IN-16 can cross the BBB[1].

• Target Antigen:

  Cholinesterase (ChE); ROS Kinase

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling;Protein Tyrosine Kinase/RTK

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ache-bche-in-9.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=C(C=CC(/C=C/C(NCC(NC2=CC=C3NC=CC3=C2)=O)=O)=C1)O

• Molecular Weight:

  365.38

• References & Citations:

  [1]Singh YP, et al. Design, synthesis and biological evaluation of novel naturally-inspired multifunctional molecules for the management of Alzheimer's disease. Eur J Med Chem. 2020 Jul 15;198:112257.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2761542-55-4