PROTAC VEGFR-2 degrader-2

• CAS Number:

  2353417-85-1

• UNSPSC Description:

  PROTAC VEGFR-2 degrader-2（PROTAC-4）, a PROTAC VEGFR-2 degrader, exhibits little VEGFR-2 inhibition (IC50> 1 μM) and anti-proliferative activity against EA.hy926 cells (IC50> 100μM)[1].

• Target Antigen:

  PROTACs; VEGFR

• Type:

  Reference compound

• Related Pathways:

  PROTAC;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-vegfr-2-degrader-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=CC=C(C(NC(NC2=CC=C(C=C2)C3=CC=CC4=C3C(N)=NN4C(CCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@@H](C[C@H]5C(NCC6=CC=C(C=C6)C7=C(N=CS7)C)=O)O)=O)=O)=O)=O)=C1)F

• Molecular Weight:

  930.10

• References & Citations:

  [1]Yuanyuan Shan, et al. Discovery of novel anti-angiogenesis agents. Part 11: Development of PROTACs based on active molecules with potency of promoting vascular normalization. Eur J Med Chem. 2020 Nov 1;205:112654.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported