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VEGFR-2-IN-19

CAT: 0804-HY-146367Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146367Size:1 Each
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Description
VEGFR-2-IN-19 (Compound 15b) is a potent VEGFR2 inhibitor. VEGFR-2-IN-19 induces cell apoptosis and increases intracellular reactive oxygen species level. VEGFR-2-IN-19 can be used as an anticancer agent[1].
CAS Number
2456315-41-4
UNSPSC
12352005
Target
Apoptosis; Reactive Oxygen Species (ROS) ; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vegfr-2-in-19.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(C=C1)NC(NC2=CC=CC=C2)=O)CC3=CC=CC=C3
Molecular Formula
C21H19N3O2
Molecular Weight
345.39
References & Citations
[1]Azimian F, et al. Synthesis and biological evaluation of diaryl urea derivatives designed as potential anticarcinoma agents using de novo structure-based lead optimization approach. Eur J Med Chem. 2020 Sep 1;201:112461.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1

Chemical Information

Vegfr-2-IN-19
CAS Number2456315-41-4
PubChem CID162668312
IUPAC Name2-phenyl-N-[4-(phenylcarbamoylamino)phenyl]acetamide
Molecular FormulaC21H19N3O2
Molecular Weight345.4
XLogP3.6
Topological Polar Surface Area70.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count2
Rotatable Bond Count5
Heavy Atom Count26
Formal Charge0
Complexity448
SMILES
C1=CC=C(C=C1)CC(=O)NC2=CC=C(C=C2)NC(=O)NC3=CC=CC=C3
InChI
InChI=1S/C21H19N3O2/c25-20(15-16-7-3-1-4-8-16)22-18-11-13-19(14-12-18)24-21(26)23-17-9-5-2-6-10-17/h1-14H,15H2,(H,22,25)(H2,23,24,26)
InChIKey
AAENGQYHFQWVKP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Vegfr-2-IN-19
CAS: 2456315-41-4
CID: 162668312
Formula: C21H19N3O2
MW: 345.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight345.4
XLogP33.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count2
Rotatable Bond Count5
Exact Mass345.147726857
Monoisotopic Mass345.147726857
Topological Polar Surface Area70.2 Ų
Heavy Atom Count26
Formal Charge0
Complexity448
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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GTR19187425-01VEGFR-2-IN-19
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MBS668224-01VEGFR-2
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BA9055-5VEGFR-2-IN-37
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