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VEGFR-2-IN-15

CAT: 0804-HY-144796Size: 1 EachDry Ice: NoHazardous: No
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Description
VEGFR-2-IN-15 (Compound 14b) is a potent VEGFR-2 inhibitor. VEGFR-2-IN-15 arrests the HepG2 cell growth at the Pre-G1 phase and induces apoptosis[1].
CAS Number
3033033-20-1
UNSPSC
12352005
Target
Apoptosis; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vegfr-2-in-15.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC=C1OC)C2=CC=C(NC(CSC3=NC4=CC(Cl)=CC=C4O3)=O)C=C2
Molecular Formula
C23H18ClN3O4S
Molecular Weight
467.92
References & Citations
[1]Elkady H, et al. New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies. J Enzyme Inhib Med Chem. 2022 Dec;37 (1) :397-410.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1

Chemical Information

Vegfr-2-IN-15
CAS Number3033033-20-1
PubChem CID163409071
IUPAC Name4-[[2-[(5-chloro-1,3-benzoxazol-2-yl)sulfanyl]acetyl]amino]-N-(2-methoxyphenyl)benzamide
Molecular FormulaC23H18ClN3O4S
Molecular Weight467.9
XLogP4.9
Topological Polar Surface Area119
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Heavy Atom Count32
Formal Charge0
Complexity649
SMILES
COC1=CC=CC=C1NC(=O)C2=CC=C(C=C2)NC(=O)CSC3=NC4=C(O3)C=CC(=C4)Cl
InChI
InChI=1S/C23H18ClN3O4S/c1-30-19-5-3-2-4-17(19)26-22(29)14-6-9-16(10-7-14)25-21(28)13-32-23-27-18-12-15(24)8-11-20(18)31-23/h2-12H,13H2,1H3,(H,25,28)(H,26,29)
InChIKey
DRDAEHHBLZRSHC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Vegfr-2-IN-15
CAS: 3033033-20-1
CID: 163409071
Formula: C23H18ClN3O4S
MW: 467.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight467.9
XLogP34.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass467.0706549
Monoisotopic Mass467.0706549
Topological Polar Surface Area119 Ų
Heavy Atom Count32
Formal Charge0
Complexity649
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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