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VEGFR-2-IN-67

CAT: 0804-HY-173365Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173365Size:1 Each
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Description
VEGFR-2-IN-67 (Compound 6b) is an inhibitor of vascular endothelial growth factor receptor 2 (VEGFR-2). Its IC50 values for MDA-231 and MCF-7 cell lines are 5.91 µM and 7.16 µM respectively, and its inhibitory effect on VEGFR-2 is comparable to that of Sorafenib (IC50 is 53.63 nM). VEGFR-2-IN-67 exerts significant anti-cancer activity through mechanisms such as inducing Apoptosis (the early apoptosis rate reaches 57.20%), arresting the cell cycle at the G1 phase, upregulating pro-apoptotic markers and downregulating Bcl-2. VEGFR-2-IN-67 can be used for research in the field of cancer[1].
UNSPSC
12352005
Target
VEGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(N1CCN(CC1)C2=NC=NC3=C2C4=C(CCCC4)S3)NC5=CC=CC(Cl)=C5
Molecular Formula
C21H22ClN5OS
Molecular Weight
427.95
References & Citations
[1]Alsfouk AA, et al. Anti-breast cancer potential of thieno-pyrimidine derivatives as VEGFR-2 inhibitors. Future Med Chem. 2025 Apr;17 (7) :803-818.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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