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VEGFR-2-IN-61

CAT: 0804-HY-170590Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170590Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VEGFR-2-IN-61 (Compound 7b) is an inhibitor for VEGFR-2 with an IC50 of 2.83 µM. VEGFR-2-IN-61 inhibits the proliferation of multi cancer cells (IC50 for MCF-7 is 2.12 μM) . VEGFR-2-IN-61 inhibits the cell migration, induces oxidative stress and apoptosis in MCF-7[1].
UNSPSC
12352005
Target
Apoptosis; Reactive Oxygen Species (ROS) ; VEGFR
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
NC1=C(C(NC2=CC=C(C(C)C)C=C2)=O)C(C3=CNC4=C3C=CC=C4)=NN1C5=CC=CC=C5
Molecular Formula
C27H25N5O
Molecular Weight
435.52
References & Citations
[1]Valapil DG, et al., Development of 3-indolyl substituted phenyl pyrazolo-carboxamide hybrids as potential type II VEGFR-2 inhibitors and in vitro cytotoxicity studies. Bioorg Med Chem Lett. 2025 Mar 1;117:130070.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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