MMP-9-IN-4

• UNSPSC Description:

  MMP-9-IN-4 is a MMP-9 inhibitor (IC50: 7.46 nM) that has H-π interactions with MMP-9. MMP-9-IN-4 also inhibits AKT activity (IC50: 8.82 nM). MMP-9-IN-4 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-4 can be used in the research of cancers[1].

• Target Antigen:

  Akt; Apoptosis; MMP

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Metabolic Enzyme/Protease;PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mmp-9-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C(N(C1=CC=CC=C1)C(C2=CC=C(C=C2)C(F)(F)F)=O)C3=CC=C(C=C3)[N+]([O-])=O)NC4=CC=C(C=C4)[N+]([O-])=O

• Molecular Weight:

  564.47

• References & Citations:

  [1]Mohammed Salah Ayoup, et al. Battle tactics against MMP-9; discovery of novel non-hydroxamate MMP-9 inhibitors endowed with PI3K/AKT signaling attenuation and caspase 3/7 activation via Ugi bis-amide synthesis. Eur J Med Chem. 2020 Jan 15;186:111875.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2581824-39-5