p53-HDM2-IN-1

p53-HDM2-IN-1

• UNSPSC Description: p53-HDM2-IN-1 is a potent inhibitor of p53-HDM2 protein-protein interaction, with an IC50 of 0.103 μM. p53-HDM2-IN-1 can be used for the research of cancer[1].
• Target Antigen: MDM-2/p53
• Type: Reference compound
• Related Pathways: Apoptosis
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/p53-hdm2-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: CCC[C@H]1N(CCC[C@@]1(OC2=CSC(C(F)(F)F)=C2)C(N3CCN(CC3)C4=CC=CC=C4OCCCC(O)=O)=O)C(C5=C(C=CN=C5O)C(F)(F)F)=O
• Molecular Weight: 772.75
• References & Citations: [1]Tian Y, et, al. Phe19 modification of HDM2-p53 PPI inhibitors to alleviate CYP3A4 metabolism/mechanism-based inhibition liability. Bioorg Med Chem Lett. 2022 Apr 1;61:128625.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported