MDM2/4-p53-IN-1

• UNSPSC Description:

  MDM2/4-p53-IN-1 is a potent MDM2-p53 and MDM4-p53 inhibitor with IC50 values of 35.9, 57.4 nM, respectively. MDM2/4-p53-IN-1 shows antiproliferative activity[1].

• Target Antigen:

  MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mdm2-4-p53-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1NC2=CC(Cl)=CC=C2[C@@]13N(N=C(C(NC4=CC(N5N=CC=C5)=CC=C4)=O)[C@@H]3C6=CC(O)=CC=C6)C7=CC=C(C=C7)Cl

• Molecular Weight:

  609.46

• References & Citations:

  [1]Espadinha M, et al. Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors. Eur J Med Chem. 2022 Aug 5;241:114637.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3037300-57-2