S100A2-p53-IN-1

S100A2-p53-IN-1

• CAS Number: 2766609-08-7
• UNSPSC Description: S100A2-p53-IN-1 (compound 51) is a S100A2-p53 interactions inhibitor. S100A2 is a Ca2+ binding protein with implications in cell signaling and is known to be upregulated in pancreatic cancer. S100A2-p53-IN-1 can inhibit the growth of the MiaPaCa-2 pancreatic cancer cell line (GI50 of 1.2-3.4 μM)[1].
• Target Antigen: MDM-2/p53
• Type: Reference compound
• Related Pathways: Apoptosis
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/s100a2-p53-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=S(NCCCNCC1COC2=C(O1)C=CC=C2)(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=O
• Molecular Weight: 498.44
• References & Citations: [1]Sun J, et, al. 3,5-Bis(trifluoromethyl)phenylsulfonamides, a novel pancreatic cancer active lead. Investigation of the terminal aromatic moiety. Bioorg Med Chem Lett. 2022 Apr 1;61:128591.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported