(rel) -Lopinavir-d8

CAT: 0804-HY-14588SSize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-14588SSize:1 mg
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Description
(rel) -Lopinavir-d8 ((rel) -ABT-378-d8) is the deuterium labeled Lopinavir (HY-14588) [1]. Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity[2][3]. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM[4].
CAS Number
[1322625-54-6]
Product Name Alternative
(rel) -ABT-378-d8
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
HIV; HIV Protease; Isotope-Labeled Compounds; SARS-CoV
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Others
Field of Research
Others
Solubility
10 mM in DMSO
Smiles
O=C1NCCCN1C([2H])(C(N[C@H](C[C@@H]([C@@H](NC(COC2=C(C=CC=C2C)C)=O)CC3=CC=CC=C3)O)CC4=CC=CC=C4)=O)C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]
Molecular Formula
C37H40D8N4O5
Molecular Weight
636.85
Precautions
H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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