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Pol I-IN-1

CAT: 0804-HY-145840Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145840Size:1 Each
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Description
Pol I-IN-1 is a potent RNA polymerase I (Pol I) inhibitor with IC50 0.21 µM for the Pol I large catalytic subunit RPA194[1].
CAS Number
2765318-69-0
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pol-i-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CN2C(C3=C(C4=C(C=C3)C=CC=C4)N=C12)=O)NCCN5CCCC5
Molecular Formula
C23H22N4O2
Molecular Weight
386.45
References & Citations
[1]Tony E. Dorado et al. Discovery and Evaluation of Novel Angular Fused Pyridoquinazolinonecarboxamides as RNA Polymerase I Inhibitors. ACS Medicinal Chemistry Letters 2022 13 (4), 608-614
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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