Pol I-IN-1
CAT:
804-HY-145840
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Pol I-IN-1
- CAS Number: 2765318-69-0
- UNSPSC Description: Pol I-IN-1 is a potent RNA polymerase I (Pol I) inhibitor with IC50 0.21 µM for the Pol I large catalytic subunit RPA194[1].
- Target Antigen: DNA/RNA Synthesis
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/pol-i-in-1.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(C1=CC=CN2C(C3=C(C4=C(C=C3)C=CC=C4)N=C12)=O)NCCN5CCCC5
- Molecular Weight: 386.45
- References & Citations: [1]Tony E. Dorado et al. Discovery and Evaluation of Novel Angular Fused Pyridoquinazolinonecarboxamides as RNA Polymerase I Inhibitors. ACS Medicinal Chemistry Letters 2022 13 (4), 608-614
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported