(S)-PERK-IN-5

• UNSPSC Description:

  (S)-PERK-IN-5 is the S-enantiomer of PERK-IN-5. (S)-PERK-IN-5 (example 39) is a PERK inhibitor, with an IC50 of 0.101-0.250 μM[1][2].

• Target Antigen:

  PERK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/s-perk-in-5.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC(C2=CC=C(NC([C@H](C3=CC(F)=CC(F)=C3)O)=O)C=C2CC)=CN=C1N)NC(C)C

• Molecular Weight:

  468.50

• References & Citations:

  [1]Calvo V, et al. Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors. Bioorg Med Chem Lett. 2021;43:128058.|[2]Alan C. Rigby, et al. Perk inhibitors for treating viral infections. WO2021231782A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2616821-92-0