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(S) -PERK-IN-5

CAT: 0804-HY-145835ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145835ASize:1 Each
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Description
(S) -PERK-IN-5 is the S-enantiomer of PERK-IN-5. (S) -PERK-IN-5 (example 39) is a PERK inhibitor, with an IC50 of 0.101-0.250 μM[1][2].
CAS Number
2616821-92-0
UNSPSC
12352005
Target
PERK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/s-perk-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(C2=CC=C(NC([C@H](C3=CC(F)=CC(F)=C3)O)=O)C=C2CC)=CN=C1N)NC(C)C
Molecular Formula
C25H26F2N4O3
Molecular Weight
468.50
References & Citations
[1]Calvo V, et al. Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors. Bioorg Med Chem Lett. 2021;43:128058.|[2]Alan C. Rigby, et al. Perk inhibitors for treating viral infections. WO2021231782A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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