PERK-IN-3

• UNSPSC Description:

  PERK-IN-3 is a potent PERK inhibitor with an IC50 of 7.4 nM[1].

• Target Antigen:

  PERK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/perk-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=CC=C(F)C(CC(N2CCC3=C2C=CC(C4=COC5=NC=NC(N)=C54)=C3)=O)=C1

• Molecular Weight:

  406.38

• References & Citations:

  [1]Axten JM , et al. Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). J Med Chem. 2012 Aug 23;55(16):7193-207.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1337532-08-7