PERK-IN-3

• Description :

  PERK-IN-3 is a potent PERK inhibitor with an IC50 of 7.4 nM[1].

• UNSPSC :

  12352005

• Target :

  PERK

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/perk-in-3.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC1=CC=C(F)C(CC(N2CCC3=C2C=CC(C4=COC5=NC=NC(N)=C54)=C3)=O)=C1

• Molecular Formula :

  C22H16F2N4O2

• Molecular Weight :

  406.38

• References & Citations :

  [1]Axten JM , et al. Discovery of 7-methyl-5- (1-{[3- (trifluoromethyl) phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl) -7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR) -like endoplasmic reticulum kinase (PERK) . J Med Chem. 2012 Aug 23;55 (16) :7193-207.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1337532-08-7]