PERK-IN-6

PERK-IN-6

• CAS Number: 1337532-14-5
• UNSPSC Description: PERK-IN-6 (Compound 5) is a PERK inhibitor with an IC50 of 2.5 nM[1].
• Target Antigen: PERK
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/perk-in-6.html
• Solubility: DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C(CC1=NC(C)=CC=C1)N2C3=C(CC2)C=C(C4=CN(C)C5=C4C(N)=NC=N5)C=C3
• Molecular Weight: 398.46
• References & Citations: [1]Axten JM, et al. Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development. ACS Med Chem Lett. 2013 Aug 12;4(10):964-8.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported