PERK-IN-2

• Description:

  PERK-IN-2 is a potent PERK inhibitor with an IC50 of 0.2 nM[1].

• UNSPSC:

  12352005

• Target:

  PERK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/perk-in-2.html

• Purity:

  99.29

• Solubility:

  DMSO : 10 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles:

  FC1=CC(F)=C(F)C(CC(N2CCC3=C2C=CC(C4=CN(C)C5=NC=NC(N)=C54)=C3)=O)=C1

• Molecular Formula:

  C23H18F3N5O

• Molecular Weight:

  437.42

• References & Citations:

  [1]Axten JM , et al. Discovery of 7-methyl-5- (1-{[3- (trifluoromethyl) phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl) -7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR) -like endoplasmic reticulum kinase (PERK) . J Med Chem. 2012 Aug 23;55 (16) :7193-207.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1337531-83-5]