PERK-IN-2

CAT: 0804-HY-135220-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-135220-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PERK-IN-2 is a potent PERK inhibitor with an IC50 of 0.2 nM[1].
CAS Number
[1337531-83-5]
UNSPSC
12352005
Target
PERK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/perk-in-2.html
Purity
99.29
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
FC1=CC(F)=C(F)C(CC(N2CCC3=C2C=CC(C4=CN(C)C5=NC=NC(N)=C54)=C3)=O)=C1
Molecular Formula
C23H18F3N5O
Molecular Weight
437.42
References & Citations
[1]Axten JM , et al. Discovery of 7-methyl-5- (1-{[3- (trifluoromethyl) phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl) -7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR) -like endoplasmic reticulum kinase (PERK) . J Med Chem. 2012 Aug 23;55 (16) :7193-207.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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