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MptpB-IN-1

CAT: 0804-HY-145741Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145741Size:1 Each
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Description
MptpB-IN-1 (Compound 13) is a potent and orally active inhibitor of MptpB. Mycobacterium tuberculosis protein-tyrosine-phosphatase B (MptpB) is a secreted virulence factor that subverts antimicrobial activity in the host. MptpB-IN-1 reduces multidrug-resistant mycobacterium tuberculosis survival and infection burden[1].
CAS Number
2244622-44-2
UNSPSC
12352005
Target
Antibiotic
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mptpb-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NOC(C)=C1C2=CC=CC(C3=CC(Cl)=C(C(Cl)=C3)O)=C2)O
Molecular Formula
C17H11Cl2NO4
Molecular Weight
364.18
References & Citations
[1]Vickers CF, et al. Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo. J Med Chem. 2018;61 (18) :8337-8352.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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