MPTP (hydrochloride)

CAT: 0804-HY-15608-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-15608-01Size:5 mg

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Description

MPTP hydrochloride is a brain penetrant dopaminergic neurotoxin. MPTP hydrochloride can be used to induce Parkinson’s Disease model. MPTP hydrochloride, a precusor of MPP+, induces apoptosis[1][2][3]. MPTP hydrochloride has been verified by MCE with professional biological experiments.

CAS Number

23007-85-4

UNSPSC

12352005

Hazard Statement

H301+H311+H331, H315, H319, H335

Target

Apoptosis; Dopamine Receptor

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/MPTP-hydrochloride.html

Purity

99.91

Solubility

DMSO : 12 mg/mL (ultrasonic; warming) |H2O : ≥ 100 mg/mL

Smiles

CN1CC=C(C2=CC=CC=C2)CC1.[H]Cl

Molecular Formula

C12H16ClN

Molecular Weight

209.72

Precautions

H301+H311+H331, H315, H319, H335

References & Citations

[1]Langston J W, Irwin I. MPTP Neurotoxicity: An Overview and Characterization of Phases of Toxicity. II. Selective Accumulation of MPP in the Substantia Nigra: A Key to Neurotoxicity (Question) . Life Sci., 1985, 36, No. 3, 201-12.|[2]Hsu K S, et al. Potentiation of MPTP by 4-Phenylpyridine on the Neuromuscular Blockade in Mouse Phrenic Nerve-Diaphragm. Neuropharmacology, 1993, 32, No. 9, 877-83.|[3]Sun XL, et al. Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models. J Neuroinflammation. 2016 Jul 8;13 (1) :180.|[4]Jackson-Lewis V, Przedborski S. Protocol for the MPTP mouse model of Parkinson's disease. Nat Protoc. 2007;2 (1) :141-51.|[5]Rabaneda-Lombarte N, et al. The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson's disease. J Neuroinflammation. 2021 Apr 6;18 (1) :88. |[6]Lee, et al. MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration. Cell Death Differ. 2019 Jan;26 (2) :213-228.|[7]Zhang QS, et al. Reassessment of subacute MPTP-treated mice as animal model of Parkinson's disease. Acta Pharmacol Sin. 2017 Oct;38 (10) :1317-1328.|[8]Hammock BD, et al., A sheep model for MPTP induced Parkinson-like symptoms. Life Sci. 1989;45 (17) :1601-8.|[9]Ren J, et al. Time association study on a sub-acute mouse model of Parkinson's disease. Heliyon. 2024 Jul 4;10 (13) :e34082.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Chemical Information

MPTP hydrochloride

MPTP hydrochloride is an organic molecular entity. It has a role as a neurotoxin.

CAS Number	23007-85-4
PubChem CID	161406
IUPAC Name	1-methyl-4-phenyl-3,6-dihydro-2H-pyridine;hydrochloride
Molecular Formula	C12H16ClN
Molecular Weight	209.71
Topological Polar Surface Area	3.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	1
Heavy Atom Count	14
Formal Charge	0
Complexity	189

SMILES

CN1CCC(=CC1)C2=CC=CC=C2.Cl

InChI

InChI=1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H

InChIKey

KOWJANGMTAZWDT-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 23007-85-4

CID: 161406

Formula: C12H16ClN

MW: 209.71

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	209.71
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	1
Exact Mass	209.0971272
Monoisotopic Mass	209.0971272
Topological Polar Surface Area	3.2 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	189
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	2
Compound Is Canonicalized	Yes

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T4081-01	MPTP hydrochloride
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A15173-25	MPTP hydrochloride 25mg
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A15173-1000	MPTP hydrochloride 1g
A15173-200	MPTP hydrochloride 200mg
A15173-5	MPTP hydrochloride 5mg
A15173-100	MPTP hydrochloride 100mg
A15173-50	MPTP hydrochloride 50mg
A15173-500	MPTP hydrochloride 500mg

MPTP (hydrochloride)

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