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MptpB-IN-2

CAT: 0804-HY-155558Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155558Size:1 Each
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Description
MptpB-IN-2 (compound 20) is a selective mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitor with IC50s of 0.64 μM, 4.06 μM and 4.14 μM for MptpB, MptpA and PTP1B, respectively. MptpB-IN-2 shows weak antituberculosis activity with a MIC of 64.9 μM for Mtb H37Rv[1].
CAS Number
3028076-11-8
UNSPSC
12352005
Target
Antibiotic
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mptpb-in-2.html
Solubility
10 mM in DMSO
Smiles
CCCC[C@@H](C(O)=O)N1C(/C(SC1=S)=C/C2=CC=C(C3=CC=CC(C(F)(F)F)=C3)C=C2)=O
Molecular Formula
C23H20F3NO3S2
Molecular Weight
479.54
References & Citations
[1]Shihao Cheng, et al. Design, synthesis and biological evaluation of 3-substituted-2-thioxothiazolidin-4-one (rhodanine) derivatives as antitubercular agents against Mycobacterium tuberculosis protein tyrosine phosphatase B. Eur J Med Chem
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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