MptpB-IN-2

• UNSPSC Description:

  MptpB-IN-2 (compound 20) is a selective mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitor with IC50s of 0.64 μM, 4.06 μM and 4.14 μM for MptpB, MptpA and PTP1B, respectively. MptpB-IN-2 shows weak antituberculosis activity with a MIC of 64.9 μM for Mtb H37Rv[1].

• Target Antigen:

  Antibiotic

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/mptpb-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCCC[C@@H](C(O)=O)N1C(/C(SC1=S)=C/C2=CC=C(C3=CC=CC(C(F)(F)F)=C3)C=C2)=O

• Molecular Weight:

  479.54

• References & Citations:

  [1]Shihao Cheng, et al. Design, synthesis and biological evaluation of 3-substituted-2-thioxothiazolidin-4-one (rhodanine) derivatives as antitubercular agents against Mycobacterium tuberculosis protein tyrosine phosphatase B. Eur J Med Chem

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3028076-11-8