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LRRK2-IN-3

CAT: 0804-HY-145318Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145318Size:1 Each
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Description
LRRK2-IN-3 (compoubd 24) is a potent, selective, orally active and brain-penetrant inhibitor LRRK2, with IC50 of 2.6 nM in human PBMCs. LRRK2-IN-3 can be used for the research of Parkinson's disease[1].
CAS Number
2641054-60-4
UNSPSC
12352005
Target
LRRK2
Type
Reference compound
Related Pathways
Autophagy
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lrrk2-in-3.html
Solubility
10 mM in DMSO
Smiles
FC1([C@@](N2C(C)=C(C=N2)NC3=NC4=C(C=C(C(C5CCN([C@]6([C@H](COC6)O)C)CC5)=C4)Cl)C=N3)([H])C1)F
Molecular Formula
C25H29ClF2N6O2
Molecular Weight
518.99
References & Citations
[1]Keylor MH, et, al. Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors. J Med Chem. 2022 Jan 13;65 (1) :838-856.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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