LRRK2-IN-3

• UNSPSC Description:

  LRRK2-IN-3 (compoubd 24) is a potent, selective, orally active and brain-penetrant inhibitor LRRK2, with IC50 of 2.6 nM in human PBMCs. LRRK2-IN-3 can be used for the research of Parkinson's disease[1].

• Target Antigen:

  LRRK2

• Type:

  Reference compound

• Related Pathways:

  Autophagy

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/lrrk2-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1([C@@](N2C(C)=C(C=N2)NC3=NC4=C(C=C(C(C5CCN([C@]6([C@H](COC6)O)C)CC5)=C4)Cl)C=N3)([H])C1)F

• Molecular Weight:

  518.99

• References & Citations:

  [1]Keylor MH, et, al. Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors. J Med Chem. 2022 Jan 13;65(1):838-856.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2641054-60-4