LRRK2-IN-14

• UNSPSC Description:

  LRRK2-IN-14 (Compound 8) is an orally active LRRK2 inhibitor. LRRK2-IN-14 has an IC50 of 6.3 nM for LRRK2(G2019S) cell activity.LRRK2-IN-14 has an inhibitory effect on hERG (IC50=22 μM). LRRK2-IN-14 has blood-brain barrier permeability[1].

• Target Antigen:

  LRRK2

• Type:

  Reference compound

• Related Pathways:

  Autophagy

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/lrrk2-in-14.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=C2C=C(C(N(CCCNC3=NC(N2)=NC=C3C(F)(F)F)C)=O)C=C1

• Molecular Weight:

  381.35

• References & Citations:

  [1]Kim K, et al. Concurrent Optimizations of Efficacy and Blood-Brain Barrier Permeability in New Macrocyclic LRRK2 Inhibitors for Potential Parkinson's Disease Therapeutics. J Med Chem. 2024 May 9;67(9):7647-7662.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2942328-06-3