LRRK2-IN-10

LRRK2-IN-10

• CAS Number: 2704562-80-9
• UNSPSC Description: LRRK2-IN-10 (compound 34) is a potent, mutation-selective, and brain penetrant G2019S-LRRK2 kinase inhibitor with IC50s of 11 nM and 5.2 nM for G2019S-LRRK2 pS935 and G2019S-LRRK2 pS1292, respectively. LRRK2-IN-10 has the potential for Parkinson's disease research[1].
• Target Antigen: LRRK2
• Type: Reference compound
• Related Pathways: Autophagy
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/lrrk2-in-10.html
• Solubility: 10 mM in DMSO
• Smiles: N#CC1=CC(CC2)=C(C=C1)[C@H]2NC3=CC4=C(C=C3)NN=C4C5=CON=C5
• Molecular Weight: 341.37
• References & Citations: [1]Albert W Garofalo, et al. Brain-penetrant cyanoindane and cyanotetralin inhibitors of G2019S-LRRK2 kinase activity.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported