LRRK2-IN-8

• Description:

  LRRK2-IN-8 is a LRRK2 inhibitor. LRRK2-IN-8 inhibits LRRK2 (wt) and LRRK2 (G2019) with IC50s lower than 10 nM, and inhibits TYK2 and NUAK1 with IC50s of 10-100 nM[1].

• UNSPSC:

  12352005

• Target:

  AMPK; JAK; LRRK2

• Type:

  Reference compound

• Related Pathways:

  Autophagy; Epigenetics; JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/lrrk2-in-8.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=CC=CC(F)=C1C2=NC3=C(C4=C(N2CCC5)N5N=C4)NN=C3

• Molecular Formula:

  C16H12F2N6

• Molecular Weight:

  326.30

• References & Citations:

  [1]Jean TASSEL, et al. Kinase modulators and methods of use thereof. Patent. WO2022104206.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  NUAK1; Tyk2

• CAS Number:

  [2770269-44-6]