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LRRK2-IN-8

CAT: 0804-HY-153058Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-153058Size:1 Each
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Description
LRRK2-IN-8 is a LRRK2 inhibitor. LRRK2-IN-8 inhibits LRRK2 (wt) and LRRK2 (G2019) with IC50s lower than 10 nM, and inhibits TYK2 and NUAK1 with IC50s of 10-100 nM[1].
CAS Number
2770269-44-6
UNSPSC
12352005
Target
AMPK; JAK; LRRK2
Type
Reference compound
Related Pathways
Autophagy; Epigenetics; JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lrrk2-in-8.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=CC(F)=C1C2=NC3=C(C4=C(N2CCC5)N5N=C4)NN=C3
Molecular Formula
C16H12F2N6
Molecular Weight
326.30
References & Citations
[1]Jean TASSEL, et al. Kinase modulators and methods of use thereof. Patent. WO2022104206.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NUAK1; Tyk2

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