CPT-Se4

CAT: 0931-T73422-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T73422-01Size:25 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2968315-03-7
Target
Apoptosis|||Topoisomerase
Related Pathways
DNA Damage/DNA Repair|||Apoptosis
Bioactivity
CPT-Se4, a seleno-derivative of Camptothecin (CPT), exhibits enhanced efficacy in cancer cell eradication and tumor suppression. It reduces the GSH/GSSG balance and total thiol content while increasing ROS concentrations in Hep G2 cells, leading to the induction of cancer cell apoptosis. Furthermore, CPT-Se4 demonstrates cytotoxicity towards a range of cell lines including HeLa, Hep G2, A549, and SMMC-7721, with IC50 values ranging from 2.54 to 6.4 ?M [1].
Smiles
CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)OC(=O)OCC[Se][Se]CCO
Molecular Formula
C25H24N2O7Se2
Molecular Weight
622.39
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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