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S-MGB-234

CAT: 0804-HY-145287Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145287Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
S-MGB-234 is a minor groove binder of Animal African Trypanosomiasis (AAT) . S-MGB-234 displays excellent in vitro activities against the principal causative organisms of AAT; Trypanosoma congolense, and Trypanosoma vivax. S-MGB-234 does not show cross-resistance with the current diamidine agents and are not internalized via the transporters used by diamidines[1].
CAS Number
1970223-53-0
UNSPSC
12352005
Target
DNA/RNA Synthesis; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/s-mgb-234.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(NC(C2=CN=C(/C=C/C3=CC=C(C=C3)OC)C=C2)=O)=CN1C)NC4=CN(C)C(C(NCCC(N)=N)=O)=C4
Molecular Formula
C30H32N8O4
Molecular Weight
568.63
References & Citations
[1]Giordani F, et al. Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model [published correction appears in J Med Chem. 2021 Dec 23;64 (24) :18236]. J Med Chem. 2019;62 (6) :3021-3035.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Trypanosoma

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