Products for Research Use Only
RegisterLogin

ROS 234 (dioxalate)

CAT: 0804-HY-107563ASize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-107563ASize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ROS 234 dioxalate is a potent H3 antagonist, with a pKB of 9.46 for Guinea-pig ileum H3-receptor, a pKi of 8.90 for Rat cerebral cortex H3-receptor, and a ED50 of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 dioxalate diaplays poor central access[1][2].
CAS Number
1781941-93-2
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ros-234-dioxalate.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C(O)=O.O=C(O)C(O)=O.C1(NCCCC2=CN=CN2)=NC3=CC=CC=C3N1
Molecular Formula
C17H19N5O8
Molecular Weight
421.36
References & Citations
[1]Ballabeni V, et al. CNS access of selected H3-antagonists: ex vivo binding study in rats. Inflamm Res. 2002 Apr;51 Suppl 1:S55-6.|[2]Mor M, et al. Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists. Bioorg Med Chem. 2004 Feb 15;12 (4) :663-74.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H3 Receptor

Chemical Information

ROS 234 dioxalate
CAS Number1781941-93-2
PubChem CID56972188
IUPAC NameN-[3-(1H-imidazol-5-yl)propyl]-1H-benzimidazol-2-amine;oxalic acid
Molecular FormulaC17H19N5O8
Molecular Weight421.4
Topological Polar Surface Area219
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count11
Rotatable Bond Count7
Heavy Atom Count30
Formal Charge0
Complexity331
SMILES
C1=CC=C2C(=C1)NC(=N2)NCCCC3=CN=CN3.C(=O)(C(=O)O)O.C(=O)(C(=O)O)O
InChI
InChI=1S/C13H15N5.2C2H2O4/c1-2-6-12-11(5-1)17-13(18-12)15-7-3-4-10-8-14-9-16-10;2*3-1(4)2(5)6/h1-2,5-6,8-9H,3-4,7H2,(H,14,16)(H2,15,17,18);2*(H,3,4)(H,5,6)
InChIKey
JKTBCMILCFDKEJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of ROS 234 dioxalate
CAS: 1781941-93-2
CID: 56972188
Formula: C17H19N5O8
MW: 421.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight421.4
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count11
Rotatable Bond Count7
Exact Mass421.12336258
Monoisotopic Mass421.12336258
Topological Polar Surface Area219 Ų
Heavy Atom Count30
Formal Charge0
Complexity331
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-107563ROS 234
HY-158013A-01JJC8-088 (dioxalate)
HY-150677SDesethylchloroquine-d5 (dioxalate)
HY-117842KY 234
HY-P1196Kisspeptin 234
HY-145306-01DX3-234
HY-P1196A-01Kisspeptin 234 (TFA)
HY-163843Antibacterial agent 234
HY-W1008737CRBN ligand-234
HY-145287S-MGB-234

Alternative Products

CatalogName
TRC-P755940-100MGProglumetacin Dioxalate
OR1038133-01Atracurium dioxalate
AR-L07407-01Lincomycin Dioxalate
B6931-50ROS 234 dioxalate
CS-SN-00042HYDROXYCHLOROQUINE DIOXALATE SALT
T89553-01JJC8-088 dioxalate
574389ROS-234 dioxalate
sc-477120Proglumetacin-d4 Dioxalate
AR-A04751-01Atracurium Dioxalate Salt
459492-01N-Methylhistaprodifen Dioxalate Salt

Popular Products