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KY 234

CAT: 0804-HY-117842Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117842Size:1 Each
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Description
KY 234 is an orally effective inhibitor that targets thromboxane A2 production, with an IC50 of 5 μM. KY 234 significantly inhibits leukotriene D4 (LTD4), histamine, and antigen-induced bronchoconstriction in guinea pigs, with IC50 values of 6.0 mg/kg, 2.5 mg/kg, and 6.3 mg/kg, respectively[1].
CAS Number
172544-75-1
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ky-234.html
Smiles
O=C(C1=CC2=C(C=C1)C(CN3C=CN=C3)=CN2CCCN4CCN(C(C5=CC=CC=C5)C6=CC=CC=C6)CC4)O[Na]
Molecular Formula
C33H34N5NaO2
Molecular Weight
555.65
References & Citations
[1]KAMIYA S, et al. Thromboxane A2 synthetase inhibitors with histamine H1-blocking activity: synthesis and evaluation of a new series of indole derivatives[J]. Chemical and pharmaceutical bulletin, 1995, 43 (10) : 1692-1695.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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