OM-1700

• UNSPSC Description:

  OM-1700 is a potent tankyrase inhibitor with IC50s of 127 and 14 nM for tankyrase 1 and tankyrase 2, respectively. OM-1700 reduces cell growth in the colon cancer cell line COLO 320DM (GI50=650 nM)[1].

• Target Antigen:

  PARP

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/om-1700.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=[C@](C=CC=C1)[N@]2C([C@]3([H])C[C@H](C3)NC(C4=CC=CC=N4)=O)=NN=C2C5=CC=C(C=N5)OCC

• Molecular Weight:

  458.49

• References & Citations:

  [1]Leenders RGG, et al. Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II. J Med Chem. 2021;64(24):17936-17949.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2406276-78-4