IMP-1700

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  IMP-1700 is an inhibitor of bacterial DNA repair.1It potentiates the activity of the quinolone antibiotic ciprofloxacin against methicillin-resistantS. aureus (MRSA) with a combination index value of 0.7. IMP-1700 inhibits the ciprofloxacin-induced bacterial SOS response, a process that repairs DNA damage, in a reporter assay in a concentration-dependent manner. It is also active againstE. coli, as well as methicillin-resistant and -sensitive S. aureus, when used alone (EC50s = 0.5, 0.21, and 3.8 ?M, respectively) .

• Smiles:

  OC(=O)c1cn(C2CC2)c2cc(N3CCN(CC3)C(=S)Nc3ccc(cc3)C(F)(F)F)c(F)cc2c1=O

• Molecular Formula:

  C25H22F4N4O3S

• Molecular Weight:

  534.53

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1458674-25-3