XY-06-007

• Description:

  XY-06-007 is a selective and potent bump-and-hole (B&H) -PROTAC BRD4BD1L94V degrader. XY-06-007 shows a DC50, 6 h of 10 nM against BRD4BD1L94V with no degradation of off-targets. XY-06-007 demonstrates suitable pharmacokinetics for in vivo studies[1].

• UNSPSC:

  12352005

• Target:

  Epigenetic Reader Domain; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/xy-06-007.html

• Purity:

  98.9

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=CC=C (C2=N[C@H] (C3=NN=C (N3C4=C2C=C (C=C4) OC) C) [C@H] (C (NCCCCCNC (COC5=C6C (C (N (C6=O) C7C (NC (CC7) =O) =O) =O) =CC=C5) =O) =O) C) C=C1

• Molecular Formula:

  C41H41ClN8O8

• Molecular Weight:

  809.27

• References & Citations:

  [1]Radosław P Nowak, et al. Structure-Guided Design of a "Bump-and-Hole" Bromodomain-Based Degradation Tag. J Med Chem. 2021 Aug 12;64 (15) :11637-11650.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Cereblon

• CAS Number:

  2757045-94-4