XY-52

• UNSPSC Description:

  XY-52 (Compound 32) is a Stimulation-2 (ST2) inhibitor, with an IC50 value of 5.68 μM in AlphaLISA assay, and 4.59 μM in HEK-Blue assay. XY-52 increases proinflammatory T-cell proliferation. XY-52 reduces the plasma sST2 and IFNγ biomarkers in the graft versus host disease (GVHD) mice model[1].

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/xy-52.html

• Purity:

  98.63

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CCN1C(CN2CCCC2C3=CC(N4CC(CC5)NC5C4)=CC=C3)=CC=C1C6=CC=C([N+]([O-])=O)C=C6C

• Molecular Weight:

  499.65

• References & Citations:

  [1]Yuan X, et al. Prophylactic Mitigation of Acute Graft versus Host Disease by Novel 2-(Pyrrolidin-1-ylmethyl)pyrrole-Based Stimulation-2 (ST2) Inhibitors. ACS Pharmacol Transl Sci. 2023 Aug 16;6(9):1275-1287.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported