XY-52

CAT: 0804-HY-155193-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-155193-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XY-52 (Compound 32) is a Stimulation-2 (ST2) inhibitor, with an IC50 value of 5.68 μM in AlphaLISA assay, and 4.59 μM in HEK-Blue assay. XY-52 increases proinflammatory T-cell proliferation. XY-52 reduces the plasma sST2 and IFNγ biomarkers in the graft versus host disease (GVHD) mice model[1].
UNSPSC
12352005
Target
Interleukin Related
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/xy-52.html
Purity
99.77
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCN1C(CN2CCCC2C3=CC(N4CC(CC5)NC5C4)=CC=C3)=CC=C1C6=CC=C([N+]([O-])=O)C=C6C
Molecular Formula
C30H37N5O2
Molecular Weight
499.65
References & Citations
[1]Yuan X, et al. Prophylactic Mitigation of Acute Graft versus Host Disease by Novel 2- (Pyrrolidin-1-ylmethyl) pyrrole-Based Stimulation-2 (ST2) Inhibitors. ACS Pharmacol Transl Sci. 2023 Aug 16;6 (9) :1275-1287.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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