XY-52

• Description :

  XY-52 (Compound 32) is a Stimulation-2 (ST2) inhibitor, with an IC50 value of 5.68 μM in AlphaLISA assay, and 4.59 μM in HEK-Blue assay. XY-52 increases proinflammatory T-cell proliferation. XY-52 reduces the plasma sST2 and IFNγ biomarkers in the graft versus host disease (GVHD) mice model[1].

• UNSPSC :

  12352005

• Target :

  Interleukin Related

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/xy-52.html

• Purity :

  99.77

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CCN1C(CN2CCCC2C3=CC(N4CC(CC5)NC5C4)=CC=C3)=CC=C1C6=CC=C([N+]([O-])=O)C=C6C

• Molecular Formula :

  C30H37N5O2

• Molecular Weight :

  499.65

• References & Citations :

  [1]Yuan X, et al. Prophylactic Mitigation of Acute Graft versus Host Disease by Novel 2- (Pyrrolidin-1-ylmethyl) pyrrole-Based Stimulation-2 (ST2) Inhibitors. ACS Pharmacol Transl Sci. 2023 Aug 16;6 (9) :1275-1287.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported