PF-4778574

• Description :

  PF-4778574 is a positive allosteric modulation of AMPA receptor with EC50 of 45 to 919 nM in differenct cells.

• CAS Number :

  [1219633-99-4]

• UNSPSC :

  12352005

• Target :

  IGluR

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/PF-4778574.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=S(N[C@@H](CCOC1)[C@H]1C(C=C2)=CC=C2C3=CC=C(C#N)S3)(C(C)C)=O

• Molecular Formula :

  C19H22N2O3S2

• Molecular Weight :

  390.52

• References & Citations :

  [1]Roberts BM, et al. Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction. Behav Brain Res. 2010 Sep 1;212 (1) :41-8.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  AMPA Receptor