CREB-IN-1 (TFA)

CREB-IN-1 (TFA)

• CAS Number: 2912285-84-6
• UNSPSC Description: CREB-IN-1 TFA is a potent, orally active CREB inhibitor (IC50=0.18 μM). CREB-IN-1 TFA inhibits breast cancer cell growth[1].
• Target Antigen: Epigenetic Reader Domain
• Type: Reference compound
• Related Pathways: Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/creb-in-1-tfa.html
• Solubility: 10 mM in DMSO
• Smiles: NCCCOC1=C(C=C2C=CC=CC2=C1)C(NCCOC3=CC4=CC=CC=C4C=C3C(NC5=CC=C(C=C5OP(O)(O)=O)Cl)=O)=O.OC(C(F)(F)F)=O
• Molecular Weight: 778.06
• References & Citations: [1]Peng J, et al. Design, Synthesis and Biological Evaluation of Prodrugs of 666-15 as Inhibitors of CREB-Mediated Gene Transcription. ACS Med Chem Lett. 2022; 13(3):388-395.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported