PPARα/δ agonist 1

• Description :

  PPARα/δ agonist 1 is a potent PPARα/PPARδ dual agonist (PPARα EC50=7.0 nM; PPARδ EC50=8.4 nM) . PPARα/δ agonist 1 is a high selectivity over PPARγ (PPARγ EC50=1316.1 nM) . PPARα/δ agonist 1 has the potential for the research of nonalcoholic steatohepatitis[1].

• CAS Number :

  [2760128-48-9]

• UNSPSC :

  12352005

• Target :

  PPAR

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/pparα-δ-agonist-1.html

• Purity :

  99.59

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1N(N=CN1C2=CC=C(C=C2)OC(F)(F)F)CC3=CC(C)=C(C(C)=C3)OC(C)(C(O)=O)C

• Molecular Formula :

  C22H22F3N3O5

• Molecular Weight :

  465.42

• References & Citations :

  [1]Feng Z, et al. Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPARα/δ Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem. 2022;65 (3) :2571-2592.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PPARα; PPARγ; PPARδ