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PPARα/δ agonist 1

CAT: 0804-HY-144111-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-144111-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PPARα/δ agonist 1 is a potent PPARα/PPARδ dual agonist (PPARα EC50=7.0 nM; PPARδ EC50=8.4 nM) . PPARα/δ agonist 1 is a high selectivity over PPARγ (PPARγ EC50=1316.1 nM) . PPARα/δ agonist 1 has the potential for the research of nonalcoholic steatohepatitis[1].
CAS Number
2760128-48-9
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pparα-δ-agonist-1.html
Purity
99.59
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(N=CN1C2=CC=C(C=C2)OC(F)(F)F)CC3=CC(C)=C(C(C)=C3)OC(C)(C(O)=O)C
Molecular Formula
C22H22F3N3O5
Molecular Weight
465.42
References & Citations
[1]Feng Z, et al. Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPARα/δ Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem. 2022;65 (3) :2571-2592.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARα; PPARγ; PPARδ

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