LEB-03-146

• Target :

  Wee1|||Others

• Related Pathways :

  Others|||Cell Cycle/Checkpoint

• Bioactivity :

  LEB-03-146, a WEE1 DUBTAC (deubiquitinase-targeting chimera), effectively links AZD1775 (Adavosertib) with the OTUB1 recruiter EN523 via a PEG2 linker. This compound demonstrates considerable WEE1 stabilization in HEP3B hepatoma cancer cells [1].

• Smiles :

  CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(CCOCCOCCNC(=O)CCc4ccc(o4)N4CCN(CC4=O)C(=O)C=C)CC3)nc12

• Molecular Formula :

  C46H57N11O8

• Molecular Weight :

  892.01

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2858812-91-4