LEB-03-146

• Target:

  Wee1|||Others

• Related Pathways:

  Others|||Cell Cycle/Checkpoint

• Bioactivity:

  LEB-03-146, a WEE1 DUBTAC (deubiquitinase-targeting chimera), effectively links AZD1775 (Adavosertib) with the OTUB1 recruiter EN523 via a PEG2 linker. This compound demonstrates considerable WEE1 stabilization in HEP3B hepatoma cancer cells [1].

• Smiles:

  CC (C) (O) c1cccc (n1) -n1n (CC=C) c (=O) c2cnc (Nc3ccc (cc3) N3CCN (CCOCCOCCNC (=O) CCc4ccc (o4) N4CCN (CC4=O) C (=O) C=C) CC3) nc12

• Molecular Formula:

  C46H57N11O8

• Molecular Weight:

  892.01

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2858812-91-4