BRPF1B/TRIM24-IN-1

BRPF1B/TRIM24-IN-1

• CAS Number: 1242907-48-7
• UNSPSC Description: BRPF1B/TRIM24-IN-1 (compound 34) is a potent TRIM24/BRPF1/BRPF2 inhibitor, with IC50 values of 0.43, 0.34, 1.75 μM, respectively. BRPF1B/TRIM24-IN-1 binds the TRIM24 bromodomain with a KD of 222 nM and has a KD for the BRPF1 bromodomain of 137 nM and for BRD1 of 1130 nM[1].
• Target Antigen: Epigenetic Reader Domain
• Type: Reference compound
• Related Pathways: Epigenetics
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/brpf1b-trim24-in-1.html
• Smiles: O=S(C1=CC=C(OC)C(OC)=C1)(NC2=C(OC3=CC=C(OC)C=C3)C=C(N4C)C(N(C)C4=O)=C2)=O
• Molecular Weight: 499.54
• References & Citations: [1]Bennett J, et al. Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF. J Med Chem. 2016 Feb 25;59(4):1642-7.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported