ABT-724

• Description:

  ABT-724, a chemical probe, is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM) . ABT-724 has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 could be useful for the treatment of erectile dysfunction and has favorable side-effect profile[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315-H319-H320

• Target:

  Dopamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/abt-724.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C1(NC(CN2CCN(C3=NC=CC=C3)CC2)=N4)=C4C=CC=C1

• Molecular Formula:

  C17H19N5

• Molecular Weight:

  293.37

• Precautions:

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations:

  [1] Brioni JD, et al. Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats. Proc Natl Acad Sci U S A. 2004 Apr 27;101 (17) :6758-63.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  D4 Receptor; D5 Receptor

• CAS Number:

  [70006-24-5]