RegisterLogin

ABT-724

CAT: 0804-HY-14330-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-14330-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
ABT-724, a chemical probe, is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM) . ABT-724 has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 could be useful for the treatment of erectile dysfunction and has favorable side-effect profile[1].
CAS Number
[70006-24-5]
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/abt-724.html
Solubility
10 mM in DMSO
Smiles
C1(NC(CN2CCN(C3=NC=CC=C3)CC2)=N4)=C4C=CC=C1
Molecular Formula
C17H19N5
Molecular Weight
293.37
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1] Brioni JD, et al. Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats. Proc Natl Acad Sci U S A. 2004 Apr 27;101 (17) :6758-63.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
D4 Receptor; D5 Receptor

Related Products

CatalogName
HY-W953266CRBN ligand-724
HY-19483ABT-670
HY-15197-01ABT-046
HY-175283ABT-002
HY-125309ABT-299
HY-101634-01ABT-072
HY-120232-01ABT-963
HY-115133ABT-116
HY-12195-01ABT-239
HY-50907-01ABT-737

Alternative Products

CatalogName
MBS5758698ABT-724
BICR201-01ABT 724
MBS3616088-01ABT 724 trihydrochloride
471047ABT-724 (hydrochloride)
M16152-01PRI-724
MBS5783755R-724
T34984UCM 724
TRC-P485380-25MGPRI 724

Popular Products