NTPDase-IN-2

NTPDase-IN-2

• CAS Number: 2883147-47-3
• UNSPSC Description: NTPDase-IN-2 (compound 5g) is a selective NTPDase inhibitor with IC50s of 0.04 and 2.27 µM for h-NTPDase-2/-8, respectively. NTPDase-IN-2 non-competitively inhibits h-NTPDase-1/-2 with a Km of 74 µM for h-NTPDase-2. NTPDase-IN-2 can be used in studies of cancer, immunologic disorders as well as bacterial infections[1].
• Target Antigen: NTPDase
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Infection; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/ntpdase-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: CC(C1=CC=C(C(F)=C1)C2=CC=CC=C2)C(NC3=NN=C(S3)SCC4=CC=CC=C4)=O
• Molecular Weight: 449.56
• References & Citations: [1]Abbas S, et al. Synthesis, characterization and biological evaluation of thiadiazole amide derivatives as nucleoside triphosphate diphosphohydrolases (NTPDases) inhibitors. Bioorg Chem. 2022 Jan;118:105456.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported