RORγt inverse agonist 29

• UNSPSC Description:

  RORγt inverse agonist 29 is a potent, orally active and selective RORγt inverse agonist (IC50: 21 nM). RORγt inverse agonist 29 can be used in the research of skin inflammation and autoimmune diseases like psoriasis[1].

• Target Antigen:

  ROR

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/rorγt-inverse-agonist-29.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCS(=O)(C1=CN=C(C=C1)CC(NC2=CC3=C(C(CC(O3)CC4=CC=CC=C4)=O)C=C2)=O)=O

• Molecular Weight:

  464.53

• References & Citations:

  [1]Lei Chen, et al. Discovery of N-(2-benzyl-4-oxochroman-7-yl)-2-(5-(ethylsulfonyl) pyridin-2-yl) acetamide (b12) as a potent, selective, and orally available novel retinoic acid receptor-related orphan receptor γt inverse agonist. Bioorg Chem. 2022 Feb;119:105483.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported