RORγt inverse agonist 29

RORγt inverse agonist 29

• UNSPSC Description: RORγt inverse agonist 29 is a potent, orally active and selective RORγt inverse agonist (IC50: 21 nM). RORγt inverse agonist 29 can be used in the research of skin inflammation and autoimmune diseases like psoriasis[1].
• Target Antigen: ROR
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/rorγt-inverse-agonist-29.html
• Solubility: 10 mM in DMSO
• Smiles: CCS(=O)(C1=CN=C(C=C1)CC(NC2=CC3=C(C(CC(O3)CC4=CC=CC=C4)=O)C=C2)=O)=O
• Molecular Weight: 464.53
• References & Citations: [1]Lei Chen, et al. Discovery of N-(2-benzyl-4-oxochroman-7-yl)-2-(5-(ethylsulfonyl) pyridin-2-yl) acetamide (b12) as a potent, selective, and orally available novel retinoic acid receptor-related orphan receptor γt inverse agonist. Bioorg Chem. 2022 Feb;119:105483.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported