RORγt Inverse agonist 8

• UNSPSC Description:

  RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist, with an IC50 of 19 nM for human RORγt-LBD[1].

• Target Antigen:

  ROR

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/ror-gamma-t-inverse-agonist-8.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CN=C(C)N=C1)NC2=CN3C(C(CN4C[C@H](C)N(C(C5CCCC5)=O)CC4)=C2C)=NC=C3

• Molecular Weight:

  475.59

• References & Citations:

  [1]Guendisch U, et al. Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo. PLoS One. 2017 Nov 20;12(11):e0188391.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2079892-79-6