RORγt Inverse agonist 8

RORγt Inverse agonist 8

• CAS Number: 2079892-79-6
• UNSPSC Description: RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist, with an IC50 of 19 nM for human RORγt-LBD[1].
• Target Antigen: ROR
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/ror-gamma-t-inverse-agonist-8.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CN=C(C)N=C1)NC2=CN3C(C(CN4C[C@H](C)N(C(C5CCCC5)=O)CC4)=C2C)=NC=C3
• Molecular Weight: 475.59
• References & Citations: [1]Guendisch U, et al. Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo. PLoS One. 2017 Nov 20;12(11):e0188391.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported