RORγt inverse agonist 14

RORγt inverse agonist 14

• CAS Number: 2672496-70-5
• UNSPSC Description: RORγt inverse agonist 14 (8e) is a potent, orally active and selective RORγt inverse agonist (EC50 of 2.5 nM) with anti-inflammatory activity. RORγt inverse agonist 14 is used in the study for rheumatoid arthritis and psoriasis[1].
• Target Antigen: ROR
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/rorγt-inverse-agonist-14.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N[C@@H]1CC[C@@]2(S(=O)(C3=CC=C(F)C=C3)=O)C4=C(N=C(C(C(F)(F)F)(F)C(F)(F)F)C=C4)CC[C@]21[H])[C@](C)(O)CS(=O)(C)=O
• Molecular Weight: 678.61
• References & Citations: [1]Qingjie Liu, et al. Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis. ACS Med Chem Lett. 2021 Apr 30;12(5):827-835.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported