Rha-PEG3-SMCC

• Description :

  Rha-PEG3-SMCC (compound 13) is a agent-linker conjugate for ADC with potent antitumor activity by using SMCC (a protein crosslinker), linked via the noncleavable ADC linker Rha-PEG3.

• CAS Number :

  [2794904-62-2]

• UNSPSC :

  12352203

• Target :

  Drug-Linker Conjugates for ADC

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/rha-peg3-smcc.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1CCC(CC1)CN2C(C=CC2=O)=O)NCCOCCOCCO[C@H]3[C@@H]([C@@H]([C@H]([C@@H](O3)C)O)O)O

• Molecular Formula :

  C24H38N2O10

• Molecular Weight :

  514.57

• References & Citations :

  [1]Kun Zhou, et al. Chemical Synthesis of Antibody-Hapten Conjugates Capable of Recruiting the Endogenous Antibody to Magnify the Fc Effector Immunity of Antibody for Cancer Immunotherapy. J Med Chem. 2022 Jan 13;65 (1) :323-332.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Traditional Cytotoxic Agents