Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO)

• UNSPSC Description:

  Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO) is a cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

• Target Antigen:

  ADC Linker

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mal-peg4-peg3-dbco-peg3-tco.html

• Smiles:

  O=C(CCC(NCCOCCOCCOCCN(C(CCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)CCOCCOCCOCCNC(O[C@H]2CCC/C([H])=C/CC2)=O)=O)N3CC4=C(C=CC=C4)C#CC5=C3C=CC=C5

• Molecular Weight:

  1205.39

• References & Citations:

  [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

• Shipping Conditions:

  Room temperature